In the broadest sense, we aim to uncover the rules by which the information encoded in the human genome governs biological processes, such as the development of complex organs and the response to signals. To do so, we are using the lens of single-cell genomics to focus on the fundamental unit of living systems, the cell. We combine the development and application of high-throughput single-cell approaches with computational analyses. Many of our projects are based on close collaborations with clinical and basic researchers here at the University of Chicago.

We are part of the Department of Medicine, Section of Genetic Medicine.